Disease Models |
BioTox Sciences CRO offers world class preclinical study applications that can help you achieve your study disease model. If the disease model that you are looking for is not listed, there is still a very good possibility that we can do it for you, and in many cases, BioTox Sciences will help you proof design the disease model at no extra charge.
In case your disease model requires development or is not listed, there is still a very good possibility that we can do it. |
Oncology Models +
| BioTox Sciences offers world class preclinical study applications that can help you in implementing your research in your desired study disease model. Not all of our disease models and in house data are published on the website so if the disease model or the in house data that you are looking for is not listed, click here to receive more information. Biotox Sciences has over 350 Xenograft cell lines, from which over 100 xenograft have been validated. We offer standard and unique animal model studies including but not limited to immune compromised Athymic nude mouse, SCID/Beige mouse and NOD.SCID mouse. As well as non-immune compromised C57BL/6 mouse. |
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| We offer standard and unique animal model studies, including: | |
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Immune and Inflammatory Disease Models +
Having done hundreds of studies in these models, BioTox Sciences can be considered an expert in many of the following models.
Arthritis
- CIA (collagen induced arthritis)
- SCW Streptococcal Cell Wall Arthritis
- Mouse Adjuvant Arthritis
- Cytokine Analysis, Histopath, X-ray analysis, Joint Swelling
Chronic Joint Inflammation
- Mouse Type II Collagen (CIA) and SCW Arthritis
- Mouse Adjuvant Arthritis
- Cytokine Analysis, Histopath, X-ray analysis, Joint Swelling
Acute Paw Inflammation
- Mouse Carrageenan and Oxazolone Paw Edema
- Mouse Zymosan Paw Edema
- Cytokine Analysis
Acute Air Pouch Inflammation
- Mouse & Rat (Carrageenan, Chemoattractant, TNF-a, IL-1b, Superantigens)
- Cytokine Analysis, Cell Number, and Cell Phenotyping (Cytospin & FACS)
Acute Inflammation
- Mouse LPS-induced inflammation (local and systemic)
- Mouse LPS/D-Gal-induced mortality
- Cytokine Analysis
Acute Rhinitis module
Dermal Irritation (Draize Modified Scoring)
Systemic Inflammation
Delayed Type Hypersensitivity (DTH)
- Mouse air pouch model with chemoattractants, superantigens, and toxins
- Mouse intraperitoneal migration model with Chemokines, superantigens, toxins and Oxazolone
- Mouse and Minipig Th1 and Th2 DTH and ACD skin migration model
- Cytokine Analysis, Cell Migration, Ex Vivo Cell Proliferation
Monosodium-Urate (MSU) crystals induced mouse neutrophil migration
- Mouse air pouch model with chemoattractants, superantigens, and toxins
- Mouse intraperitoneal migration model with Chemokines, superantigens, toxins and Oxazolone
- Mouse and Minipig Th1 and Th2 DTH and ACD skin migration model
- Cytokine Analysis, Cell Migration, Ex
Chronic CNS Inflammation
- Mouse Experimental-Induced Encephalomyelitis (EAE) (Acute B6 Mice, SJL, Biozzi Mice)
- Spontaneous EAE mouse B6/RAG/TR model
- Cytokine Analysis, Cell Proliferation
Gastrointestinal Inflammation/Irritation (colitis models)
- Colonic Inflammation: Mouse Dextran Sulfate and Oxazolone Models
- Acute Gastric Irritation in mice (4 hr)
- 3-day Intestinal Irritation in mice (72 hr)
- Cytokine Analysis, colon assessment and histopath
Asthma and COPD
- Mouse Ovalbumin asthma model
- Mouse Cockroach asthma model
- Mouse PPE induced COPD
- Smoke induced COPD
- Cytokine Analysis, cell differential count in broncho-alveolar lavages
Liver and lung fibrosis models
- Liver fibrosis (CCL4 and DNFB induced) and Lung fibrosis (Belomycin induced)
Mouse Ovalbumin asthma model
Dermatitis models
- Atopic dermatitis in NcNGA transgenic mice
- DNFB induced dermatitis in mice and pigs
- Engraftment of human Psoriatic skin in mice
- IL-12/lps-induced human like psoriasis in scid mice
Diabetes Type 1 and Type 2 +
We provide different types of diabetic models in small and large animals. Please contact us for information about your specific study design requirements.
- Mouse
- Rat
- MiniPig
Wound Healing +
With many models designed in house, BioTox Sciences has performed hundreds of wound healing studies and has many models established. BioTox Sciences offers a vast array of expertise in wound healing which can be readily available to our clients or can be used to support your specific dermal study needs.
- Mice
- Rat
- MiniPig (deep wounds, long term)
Central Nervous System +
Biotox sciences core competency in the area of CNS is based on IND enabling study requirements. BTS has established a long term collaboration with Neurocore LLC, to expand into some of the following areas.
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In collaboration with Neurocore LLC, the following models can be performed;
Neurodegeneration
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Behavioral Screening
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Click here to view Neurocore LLC
Various Models +
Some of the models that BioTox has established are listed below. If your disease model is not listed, feel free to contact us to discuss our abilities as we are always expanding our capabilities.
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